What Is Somatic Cell Nuclear Transfer (SCNT)?
Related News: Stem Cell DefinitionsSomatic Cell Nuclear Transfer (SCNT) is another name for therapeutic cloning (which is NOT the same as Reproductive Cloning .. i.e. Dolly the Sheep), and in some cases the root of the overall stem cell debate within the US States.
To fully understand this process involded in SCNT, a short course on embryology and cellular physiology must be undertaken. We will try to keep it as short and simple as we can.
When talking about cellular physiology, remember that every cell contains a cell membrane which consists mainly of lipids or fats. This membrane separates the interior of the cell from the exterior.
Within the cell is another part, called the nucleus, which is also seperated by a membrane. Located within the nucleus the DNA. All the information that defines a cell is encoded within the DNA....
Now, back to High School Sex-Ed, we all know essentially that when a sperm meets an egg a new cell is formed. This cell has the potential to form all parts of an organism, be it mouse, rat or human (as it pertains to which ever cell egg and sperm cells we are talking about naturally).
Once this new cell has formed it begins to divide into 2, and then 4 and 8 and so on ...
This is where Somatic Cell Nuclear Transfer starts. It is possible to remove the nucleus of an unfertilized egg (as in before fertilization), and replace it with the nucleus of other cells (such as liver or heart cells). Once the new nucleus is inserted, the cell must be treated with an electric shock to stimulate or restart division.
This cell, with the new nucleus is now essentially a stem cell that is capable of growing into the new organ (again ... for example a liver).
This process IS NOT reproductive cloning, though that can in theory be done using similar methods.
Effectively, with SCNT, we have the means to develop new cells that are effectively "clones" of existing cells (not clones of a full body). The goal of this research is to use SCNT to effectively create new heart, liver, spinal or pancreatic cells for reimplantation into patients that have failing or faulty organs.
Projecting forward (WAYYYY forward), the goal of many of the researchers would be that a patient with heart disease or Parkinsons would be able to come to a lab and essentially get an injection of heart of brain stem cells (essentially their own cells genetically speaking) that would then migrate within the body to the damaged organ and repair that damage.
More definitions later, but I hope this clears things up a bit.
Posted on February 15, 2005 12:28 AM