Bone and Cartilage Archives
Bone Repair Using Patient's Stem Cells
Researchers at the University of Twente, The Netherlands, have just shown that if the enzyme PKA is previously activated in the stem cells in the lab, following implantation, results in substantial bone formation.
This opens up new ways of repairing bone tissue using cell material from the patient.
Enzyme induces adult stem cells to grow bone, but now it has been difficult to induce adult human stem cells to produce bone, e.g. in order to repair bone tissue.
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Posted on May 27, 2008 12:09 PM | Comments (0)
Australian Stem Cell Researchers Seeing Bone Repair Benefits
At the Royal Melbourne Hospital in Australia the Director Richard de Steiger has set into a patient's left thigh bone his own stem cells.
He inserted about 30 million stem cells into a cavity in Mr Stevens's left thigh bone, which then has been coated on with "scaffolding" made of bone-like material.
The stem cells that were used have been harvested from the patient's bone marrow during a biopsy about seven weeks earlier and cultured into bone-producing cells.
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Posted on April 7, 2006 07:28 PM | Comments (0)
Stem Cell Research To Help Athletes' Tendons and Ligaments
A new approach for tendon regeneration is is being announced in the April issue of the Journal of Clinical Investigation. Stem cell Researchers Prof. Dan Gazit is leading a team at the Skeletal Biotechnology Laboratory at the Hebrew University Faculty of Dental Medicine in Israel where they are developing procedures using mesenchymal stem cells (MSCs). These stem cells are found in the bone marrow as well fat tissues.
Gazit and his team have engineered these cells express a protein called Smad8 and another called BMP2.
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Posted on April 6, 2006 01:08 PM | Comments (0)
Stem Cell Research Hits No Ethical Nerves When Treating Horses
A stem cell research firm in Singapore has been working on giving Asian racehorse owners a new way of treating tendon and ligament injuries. This news follows other news regarding stem cell research for horses that allows treatment and therapies to be developed without ethical concerns.
EZ Stemcell's therapy starts out with harvesting bone marrow from the horse's own sternum. EZ Stemcell then isolates multi-potential stem cells, which are then reinjected into the horse's injured tendon.
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Posted on March 28, 2006 05:36 PM | Comments (0)
Bones See Positive Repairs From Somatic Stem Cell Therapies
The annual meeting of the American Academy of Orthopaedic Surgeons, somatic adult stem cells were showing that they can fully repair recalcitrant tibial nonunion in 6 months or less in an ongoing phase 2 study.
Early results were presented of the "United States phase 2 fracture trial" by lead investigator Matthew L. Jimenez, MD, from the Illinois Bone and Joint Institute and Lutheran General Hospital in Chicago. Dr. Jimenez described robust repair of atrophic nonunions in all patients that participated in the study.
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Posted on March 27, 2006 02:11 PM | Comments (0)
Stem Cell Researchers Investigate Replacing Bone Graft Procedures
A lecture at the American Academy of Orthopaedic Surgeons' (AAOS) Meeting, a panel of orthopaedic surgeons from the Orthopaedic Research Society (ORS) discussed a new technique to replace bone grafts.
The hope is that adult stem cell therapy for broken bones can minimize the need for the traditional "autograft" procedures in the cases of severe bone injury where patients are not healing normally.
Many patients with these kinds of severe injuries usually undergo multiple reconstructive operations that often require a bone graft, or autograft. An effective stem cell therapy offers a significantly less painful solution to treat simple and complex fractures, particularly those that require additional time to fully heal.
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Posted on March 23, 2006 12:00 PM | Comments (0)
Aastrom Biosciences Partners With Orthovita For Orthopedic Therapies
Some hope for my bad knee cartilage afterall ... Aastrom Biosciences, a fairly well known stem cell research company from Michigan is announcing a partnership in preparation to move their adult stem cell technologies onto the marketplace.
Aastrom has announced an agreement with Pennsylvania based Orthovita Inc., which is a biomaterials company with the goal to jointly develop orthopedics products.
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Posted on March 22, 2006 12:06 AM | Comments (0)
Fast Growing Stem Cells Found In Wisdom Teeth
It was quite a long time ago since we looked at stem cells and teeth. The focus here is a little different as these stem cells derived from cells within teeth are being used to differentiate into either bone or liver tissue.
The National Institute of Advanced Industrial Science and Technology's Research Institute (AIST) for Cell Engineering is working with a team of researchers from Osaka University in Japan and have succeeded in repairing damaged liver and bones in rats by injecting stem cells derived from wisdom tooth germ.
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Posted on March 10, 2006 11:48 PM | Comments (0)
Muscle Stem Cells Into Cartilage?
Well, hope for my blown knee keeps getting closer. Yesterday, Forbes ran an article about researchers which are saying that they have turned adult muscle stem cells into cartilage. Furthmore, (sigh of relief here) the stem cells were used in animals to heal the kind of damage caused by arthritis.
For those of us that face eventual joint-replacement surgery because there is no current technique to repair cartilage damage from osteoarthritis, the wear-and-tear condition that afflicts many older people (and younger .. I am not that old).
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Posted on January 31, 2006 03:47 PM | Comments (0)
Aastrom Biosciences Receives NIH Grant Extending Proprietary Adult Stem Cell Process to Other Tissues
ANN ARBOR, Mich., Aug. 16 /PRNewswire-FirstCall/ -- Aastrom Biosciences, Inc. (Nasdaq: ASTM - News) today announced that it has received a Small Business Innovation Research Phase II grant from the National Institutes of Health (NIH) entitled "Clinical-Scale Production of Osteoprogenitor Cells." The two- year Phase II grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) totals $740,000, of which $324,000 has been received for the first year of this study. This Phase II grant award follows a Phase I grant issued to Aastrom in 2003 by the NIH's National Institute of Arthritis and Musculoskeletal and Skin Diseases.
...Posted on August 16, 2005 02:36 PM | Comments (0)
Is Osteoporosis Simply Fat Filling Up Old Bones?
Back in the 1930's, doctors found in autopsies, that inside the bones, deep in the marrow, fat cells had grown. Furthermore, as the people got older, the more their bones were filling with fat. This may not sound that hot an issue, but for sufferers of Osteoporosis, this news is the beginning of something that will certainly have an impact going forward.
"You start out with basically zero fat," said Dr. Jeffrey Gimble of the Pennington Biomedical Research Center in Baton Rouge, La. "At the time of birth, you have just a little bit of fat in the bones of your fingertips."
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Posted on July 27, 2005 04:57 PM | Comments (0)
UNMC To Participate In Clinical Trial Using Adult Stems Cells To Enhance Bone Healing
Yesterday was the day of heart and stem cell research news. It appears that today is the day for bone related stem cell news. Makes a guy with a limp smile.
The University of Nebraska Medical Center has become the fifth site in the U.S. to enter into a clinical trial with Aastrom Biosciences, Inc., to determine if special adult stem cells can help speed the healing of severe leg fractures and eliminate the need to do painful bone grafting procedures.
Candidates for the Phase I/II trial are patients with open or non-union fractures of the long bones in the leg. Open or non-union fractures are ones that haven’t completely healed within four months.
Posted on July 27, 2005 04:20 PM | Comments (0)
New Method Proves It Possible To Grow Bone For Grafts Within A Patient's Body
These of the kinds of press releases that make my sore knee less sore.
An international team of biomedical engineers has demonstrated for the first time that it is possible to grow healthy new bone reliably in one part of the body and use it to repair damaged bone at a different location.
The research, which is based on a dramatic departure from the current practice in tissue engineering, is described in a paper titled “In vivo engineering of organs: The bone bioreactor” published online this week by the Proceedings of the National Academy of Sciences.
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Posted on July 27, 2005 04:11 PM | Comments (0)
A Step Forward in Stem Cell Research
NEW YORK, June 27, 2005 - According to research published today, investigators from Memorial Sloan-Kettering Cancer Center (MSKCC) have used new techniques in the laboratory that allowed them for the first time to derive unlimited numbers of purified mesenchymal precursor cells from human embryonic stem cells (HESCs).
Mesenchymal precursor cells are capable of giving rise to fat, cartilage, bone, and skeletal muscle cells, and may potentially be used for regenerative stem cell therapy in bone, cartilage, or muscle replacement.
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Posted on June 29, 2005 03:36 PM | Comments (0)
Osiris Therapeutics Lands Additional $50M for Stem Cell Research Trials
Baltimore biotechnology company Osiris Therapeutics announced this past Wednesday that it has arranged $50 million in financing. This funding will help kick start three clinical trial programs to commercialize its adult stem cell therapy products.
This latest round, both a combination of equity and convertible debt, was made possible by Swiss investment firm Friedli Corporate Finance Inc. Peter Friedli is an Osiris co-founder and longtime financial backer who current sits on the chair of Osiris' board.
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Posted on June 14, 2005 06:32 PM | Comments (0)
Aastrom Biosciences Reports Positive Bone Repair Results In Clinical Feasibility Trial
Ann Arbor, Michigan, May 17, 2005 -- Aastrom Biosciences, Inc. (Nasdaq: ASTM) announced today the results from its feasibility clinical trial conducted with the Institut de Terapia Regenerativa Tisular (ITRT) in Barcelona, Spain to evaluate the use of Aastrom's Tissue Repair Cells (TRCs) for the treatment of severe long bone non-union fractures. A report with details of the clinical study is being filed today on Form 8-K with the SEC, providing information on each patient treatment and the results obtained. The report states that all of the patients treated with Aastrom's TRCs, an autologous bone marrow-derived cell product, exhibited clinical and functional healing, with 5 of 6 treatments showing bone regeneration at the fracture site as determined by radiographic imaging by 6 months. The results were notable in that each patient had failed prior treatment with standard of care methodologies and had a poor prognosis for healing. This feasibility trial suggests that Aastrom's autologous TRCs may offer a new way to achieve local bone regeneration for bone grafting and other clinical indications for bone repair. In addition to the Form 8-K filed with the SEC, the report detailing the results from the feasibility clinical trial in Barcelona may be accessed on Aastrom's website using the following link: http://www.aastrom.com/pdf/Whitepaper_Barcelona-051205.pdf.
...Posted on May 17, 2005 10:20 PM | Comments (0)
Stem Cell Treatments In Horses For Tendon Injuries
An 11 year old horse that suffered a tendon injury in March of 2004, underwent a stem cell treatment recently. Co-owner Nick Mills went to Britain's VetCell BioScience Ltd., which, in partnership with the Royal Veterinary College of London, has developed a method of using stem cell technology to repair damaged tendons and ligaments.
The treatment involved extracting bone marrow from the horse's sternum while it was under sedation. The bone marrow, was then taken to a laboratory where the stem cells were isolated and multiplied to more than four million cells. The cells were then suspended in a bone marrow supernatant before being injected into the site of the injury. The goal of this type of treatment was to promote the re-growth of flexible tendon tissue, rather than allowing less pliable and more injury-prone scar tissue to form. ...
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Posted on May 16, 2005 10:40 PM | Comments (0)
Bones Day, Bit Off Topic: UCLA Researchers Discover New Method to Generate Human Bone
Today there was some more news regarding research bones and cartilage. Not directly related to stem cell research, but since I already posted the article regarding growing cartilage by way of stem cell research, this seemed relevant. Additionally its good news for me personally on the quality of life front, though this is more targetting healing bone fractures by way of stimulating bone growth ..
Straight out of UCLA:
Date: April 21, 2005
Contact: Melissa Abraham ( mabraham@support.ucla.edu )
Phone: 310-206-0540
By studying diseases in which the human body generates too much bone, UCLA researchers have discovered and isolated a natural molecule that can be used to heal fractures and generate new bone growth in patients who lack it.
Bioengineering professor Ben Wu at UCLA's Henry Samueli School of Engineering and Applied Science, and Kang Ting, Thomas R. Bales Professor at UCLA's School of Dentistry, are developing a new molecule they've named UCB, or University of California Bone.
...Posted on April 22, 2005 10:00 PM | Comments (0)
More Stem Cell Research Involving Cartilage From Johns Hopkins
In the constant search to treat my own infuriating knee issues, all the while knowing there are many out there that have worse, we have found some news here that I missed this week from Johns Hopkins.
We are still waiting to hear some real news regarding Cartilix, but I suppose this will have to do. I know the company has incorated and does have a website that is under construction, but no real corporate news yet. This article also mentions Jennifer Elisseeff, that was refered to in MIT's Technology Review when discussing the company.
Regardless .. here is the news release:
Student Looks for Cell Damage in the Use of Hydrogels
to Repair Injured Cartilage
In a Johns Hopkins tissue engineering lab where researchers are making new materials to repair injured knees, noses and other body parts, an undergraduate is performing critical experiments to determine whether this promising technique might damage cells.
Athar Malik, a senior biomedical engineering major from Novi, Mich., is conducting a study to determine if DNA in cells can be harmed by a chemical reaction that occurs during the tissue engineering process. His experiments in the laboratory of Jennifer Elisseeff, an assistant professor of biomedical engineering, have been supported by a Provost's Undergraduate Research Award from the university.....
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Posted on April 22, 2005 06:49 PM | Comments (0)
Tissue Engineering and Cell Therapy Showing Proof-of-Concept, Encouraging Continued Investment and Acquisition, According to New Report from MedMarket Diligence, LLC
"There is no question but that the potential markets for cell therapy and tissue engineering are huge," says Patrick Driscoll, President of MedMarket Diligence. "But a current market of roughly $150 million worldwide, earned against the backdrop of hundreds of millions of investment, point up that the industry is a long way from a breakeven point. But even for this nascent industry, the preclinical successes as well as the limited markets already established appear to be more than sufficient to continue the investment and development drive toward realizing the market potential."
At this time, tissue engineering is occurring in the areas of Skin, Cartilage and Bone; the worldwide market for these areas is estimated to be $144.6 million. The total market by 2015, covering the areas of Skin, Bone, Cartilage, Cardiovascular, and Other (Dental and Organ Regeneration or Replacement) is predicted to be about $2.1 billion, with a compound annual growth rate of 28%.
Posted on April 16, 2005 10:53 PM | Comments (0)
Additional Stem Cell Articles In This Category
* OffTopic .. Only a Little .. Inkjet Nozzles To Spray Live Human* Osiris Cleared by FDA to Begin Stem Cell Trial for Knee Repair; T
* NJIT Presidential Award Winner Takes Stem Cell Research Another S
* More on Stem Cells and Bones - Cartilix on Scaffolds for Stem Cel
* Washington: Stem Cells May Me Used to Grow New Teeth
* Aastrom Biosciences Announces FDA Approval for Expanded Clinical
* Aastrom Biosciences Announces FDA Approval for Clinical Trials
* Canada: Connective Tissue Stem Cells To Treat Cartilage and Bone
* Canada: Toronto Researchers Have Discovered New of Stem Cell Sour
* Safety Endpoint for TRC Product Reached - Trial Expanded
* More Cartilage Digging brings me more on Jennifer Elisseeff's wor
* Jennifer Elisseeff's More Recent Work on Cartilage Replacement St
* With so many searches hitting our site for Cartilix ..
* Though Old News .. Everyone Seems to Want News on Cartilage
* Stem Cell Cartilage Treatment for Arthritis