Brain Stem Cells To Fight Cancer

Related News: Spinal / Nervous / Brain

Research at Lund University in Sweden provides hope that in the future it may be possible to develop stem cells from the brain into a new way to treat gliomas.

Neural stem cells have been shown to have the ability to recognize signals from tumor cells in the brain and migrate there. If stem cells are injected into a part of the brain in laboratory animals with a glioma in another part of their brain, the stem cells migrate over to the tumor area.

This has spawned the idea of having stem cells transport drugs or immune stimulants to the tumor. This was the principle the Lund scientists wanted to test. But as it turned out, no extra assistance was needed: the stem cells themselves had the ability to combat the tumor.

"We were truly amazed when we saw this effect! To be sure about the phenomenon, we ran several experiments with other stem cells, and it was confirmed that certain neural stem cells actually have an anti-tumor effect," says Karin Staflin. She is describing the findings in her dissertation, which she will soon defend.

One plausible reason as to why this happens is that both normal neural stem cells and glioma cells are immature, not fully mature cells. They are therefore more like each other than any other types of cells in the brain, which may enable them to communicate to each other and influence each other. The research team at Lund has also shown that stem cells can cure colon cancer in lab animals.

"Cells in aggressive malignant cancer forms are often characterized as being more immature than their environment. This may be what enables neural stem cells to affect intestinal cancer cells," says Karin Staflin.

Before having the newly discovered principle ready to be tested on humans, the researchers need to learn to understand the mechanisms better and identify the factors in neural cells which make them so effective. The notion is still new, but it does provide a glimmer of hope for a cure for a thus far incurable disease.



Posted on January 19, 2007 08:08 AM

 
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