Cytori Therapeutics Demonstrates Adipose-Derived Adult Stem and Regenerative Cells Enhance Cardiac Function in Preclinical Study
Related News: Stem Cell Companies, Stem Cell InvestmentData Featured in One of Four Cytori Presentations at Annual Adipose Biology Meeting
San Diego, CA, September 12, 2005 - Cytori Therapeutics, Inc. (Frankfurt: XMP), today announced preclinical results that support therapeutic opportunities for adult stem and regenerative cells derived from adipose, also known as fat tissue, in the treatment of cardiac injury following acute myocardial infarction (heart attack).
These data, along with three other Cytori presentations, are being featured at the third annual International Fat Applied Technology Society conference September 10-13, 2005 in Charlottesville, Virginia.
In a presentation entitled, "Adipose tissue-derived stem cells enhance cardiac function following surgically induced myocardial infarction," Cytori, in collaboration with researchers from the University of California, Los Angeles, illustrated that adipose derived stem and regenerative cells can improve left ventricular function after an acute myocardial infarction, or heart attack. In the study, rats were injected in the left ventricle with either adipose derived stem and regenerative cells or saline solution following heart attack. After 12 weeks, rats treated with adipose derived stem and regenerative cells demonstrated significant improvements in commonly accepted measures of heart function including contractility, ejection fraction (pumping of blood), tissue damage and other measures.
"These findings, combined with our additional data presented by Cytori at the conference, confirm the broad therapeutic opportunities for adipose stem and regenerative cells in multiple disease areas, including cardiovascular injury," stated Christopher J. Calhoun, Chief Executive Officer for Cytori Therapeutics. "The ability of these stem cells to contribute to the repair of multiple tissue types is particularly important given that adipose tissue is the most abundant known source of adult stem cells."
Additional presentations at the International Fat Applied Technology Society conference by Cytori and its collaborators include:
"Adipose-derived stem cells express multiple genes in common with embryonic stem cells: are adult stem cells more plastic than we think?" which discusses research indicating that adult stem cells may have greater differentiation potential than previously thought
"Adipose-derived stem cells in experimental animals: relevance to clinical studies," which shows that large animals such as dogs and pigs may provide a good proxy for predicting the effects of adipose stem cells in humans
"Regulatory affairs and the FDA," a panel involving Cytori President Marc H. Hedrick, M.D., discussing the clinical development of adipose-derived stem cell products
Posted on September 22, 2005 04:19 PM