What Is Altered Nuclear Transfer?

Related News: Stem Cell Definitions

With the politics and hype around stem cell research, the latest buzz phrase being passed around is "altered nuclear transfer".

Alterned nuclear transfer is being put forward by bioethicists as a possible ethical work-around to embryonic stem cell research and the creation of embryos involved in Somatic Cell Nuclear Transfer (SCNT)....



Currently, Altered Nuclear Transfer is defined and being promoted by Dr. William Hurlbut, a Stanford bioethicist as a solution to ethical questions involved in stem cell research. The goal in this procedure being how to create stem cells without creating a developed embryo. That brings to the the question .....



What Is Altered Nuclear Transfer? (ANT?)

The intent is to create embryonic masses of cells that could never develop into a complete human embryos, while still producing stem cells. This process has been demonstrated in mouse cells that had genetic mutations that caused the embryos to die at the blastocyst stage.

Altered Nuclear Transfer would be similar to SCNT in that cellular nuclear material from one set of human cells is transfered into another set of human cells. The key difference is that the resulting cells should carry a mutation that causes cell death at the blastocyst stage, thereby never developing in theory into a full embryo.

This process has never been tested on human cells to date, and has only been demonstrated on mouse cells, and is not current supported by many medical organizations .. like the New England Journal of Medicine as an example.



Posted on February 22, 2005 11:20 AM

 
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