Illinois: UofI in Chicago Evaluates Stem Cells for Breast Implants
Related News: Cosmetic, Stem Cell ResearchSilicone or Saline breast implants could one day be a thing of the past. The latest research looks at replacing the current implants with tissue grown from a person's own stem cells within a decade, suggests new research.
Jeremy Mao of the University of Illinois, in Chicago, US, took human stem cells and used these to grow fat tissue using a biologically compatible scaffolding. He then successfully implanted the tissue into mice with an immune deficiency to prevent them from rejecting the implants. The implants had maintained their size and shape after four weeks.
"This is a project that builds on previous knowledge to develop a stem cell material that could be useful in society," says Mao. "It seems promising and could soon be making an impact."
Implants grown from stem cells could provide a safer alternative to silicone or saline implants, which can rupture and also interfere with breast cancer detection. They could also be aesthetically superior, keeping their shape and size for longer than artificial inserts, which typically shrink by 40% to 60% over many years, through spreading.
Eventually Mao says the technique could be used to develop more suitable tissue for reconstructive surgery as well as cosmetic augmentation.
The experiment involved key-hole surgery to extract mesenchymal stem cells from human bone marrow. These "master cells" can grow into various other different types of cells, including bone cartilage and fat. Mao coaxed them to develop into fat cells by mimicking the conditions that would cause this to happen in the human body.
The cells were then moulded into shape using a hydrogel scaffold and inserted into mice for a period of four weeks. Following implantation the eight mice involved in the study suffered no discernable ill effects and their implants maintained their original size and shape for the entire month. This is substantially longer than artificial inserts, which normally begin to deform after a week or two.
Mao believes breast implants grown from stem cells could be available within a decade. Ideally, the scaffold would disintegrate safely inside the body as the implant grows, he says.
Posted on February 21, 2005 12:27 PM